- A small study in NeuroImage: Reports has found more evidence of reduced blood flow to the brain of people with Long COVID. The authors concluded that this abnormality was linked with fatigue, after they assessed brain imaging results of 22 people with Long COVID and compared them with 19 controls. Participants of the study performed a 20-minute cognitive test called psychomotor vigilance task (PVT), while undergoing a type of MRI that tracks blood flow. People with Long COVID reported much higher fatigue than controls both before and after the task, and “exhibited significantly longer reaction times during the PVT,” the authors concluded.
- The U.S. is ill-equipped to respond to Long COVID and future mass disabling events, a new analysis argues in The Journal of Medical Humanities. Author Philip Finkelstein evaluated the disease through the lens of securitization, or, how public challenges are viewed as existential security threats. He found that modern security strategies remain “shortsighted and poorly attuned to threats that operate insidiously, eroding societies from within.” He stated that to properly address the security of Long COVID on society, the U.S. would need to invest in long-term care, workplace accommodations, and social support, but that these solutions are not “geopolitically advantageous.”
- A recent preprint shared in Research Square assessed over 700 Long COVID clinical trials and found that they emphasized treating symptoms. Only 57 of the 714 trials addressed post-exertional malaise (PEM), prevalent in a subtype of Long COVID, and only eight of those trials used PEM as primary endpoint. “There is a substantial unmet need for well-powered, mechanism-based, disease-modifying trials with biomarker-driven designs and objective, exertion-based endpoints,” the researchers concluded. Still, researchers stated they used a conservative research strategy, which may have missed some studies.
