Science
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How to interpret clinical trial results for Long COVID
With no proven treatments or cures, many people with Long COVID are turning to off-label medications, supplements, and medical devices to treat their symptoms. There are numerous options — and some of them even have clinical trials underway or are reporting results. But even if one study suggests a treatment might work, another might contradict…
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Research updates, July 21
The dementia drug donepezil helped decrease fatigue in a subset of people with Long COVID, according to a study published in Frontiers in Pharmacology. In the complex study, which also included testing in mice, Japanese researchers found a majority of people with Long COVID in the cohort had reactivated human herpes virus 6 (HHV-6), which produced…
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Experimental peptides are being advertised for Long COVID. But the evidence is trailing behind.
Some FDA-approved GLP-1s are being studied in clinical trials for the disease, but their results aren’t available yet. Experts caution against using experimental peptides for Long COVID.
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Research updates, July 14
COVID-19 can cause long-term eye disorders, according to a cross sectional study in Nature Communications. Researchers in Sweden assessed 100 people with Long COVID and compared them to 32 people who had COVID-19 and “recovered.”
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Research updates, July 7
An autopsy study found persistent SARS-CoV-2 virus in the hearts of some people who had died after having COVID-19. A part of the National Institute of Health’s RECOVER program, the researchers shared their unpublished results in a poster at a pathology conference this spring.
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Research updates, June 30
A recent imaging study in Sage Journals identified metabolic dysfunction in the brains of people with Long COVID who experience PEM. The study assessed 40 people with the disease from a Long COVID clinic with an advanced imaging technique that can detect various cancers and neurologic conditions.
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FDA approves COVID-19 antiviral Xocova as PEP. But will it be accessible?
Shionogi, the Japanese company that makes Xocova (ensitrelvir), said the post-exposure prophylaxis drug will be available in mid-July in the U.S. and will have a list price of $1,400. But its impact will hinge on how easily people can access it, experts say.
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Research updates, June 23
A new study found that people with Long COVID were significantly more likely to experience cardiovascular disease after COVID-19. Published in Clinical Medicine Insights: Cardiology, researchers assessed a retrospective cohort of over 8,000 people who had a prior SARS-CoV-2 infection, discovering that Long COVID symptoms were associated with higher odds of cardiovascular disease, particularly angina…
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Research updates, June 16
Two recent studies have added more evidence that the diabetes drug metformin can reduce the risk of Long COVID.
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Research updates, June 9
A new study published in Alzheimer’s and Dementia found more evidence of alterations associated with Alzheimer’s disease in people with Long COVID. Notably, scientists identified a larger choroid plexus, a region of blood vessels in the brain, as well as reduced cerebral blood flow.
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