National COVID-19 trends, January 27

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Graphic from The Sick Times sharing the latest COVID-19 trends for January 27, 2026. The graphic presents trends for three metrics: WastewaterSCAN category for SARS-CoV-2, which is "high" (represented with an orange color) and reports a slight decrease (represented with a diagonal down arrow); CDC wastewater viral activity level for SARS-Cov-2, which is "moderate*" (orange) and reports a significant decrease (arrow going straight down); and CDC COVID-19 test positivity, which is moderate (darker yellow) and stable (side to side arrow). Text below these metrics reads: "*CDC wastewater viral activity levels are calculated based on measurements in the last two years only. They do not account for the lower spread that could be possible with more widespread precautions."
Heather Hogan / The Sick Times

Several national COVID-19 metrics have now reported two weeks of declines, suggesting we have passed the peak of this winter’s wave — but higher disease levels may continue for many more weeks. This wave has hit the Midwest and Northeast much harder than the West and South; watch for potential increases in the latter two regions later in the winter. Flu also remains a concern.

The three major wastewater surveillance sources (the CDC, WastewaterSCAN, and Biobot Analytics) all agree that SARS-CoV-2 levels are declining nationally as of mid-January. The CDC reports a more pronounced decline than the other two sources, which could be a result of states with the most testing sites — several of which are in the Midwest and Northeast — skewing the national average.

As I noted last week, this winter’s peak has been notably lower than the peaks of prior winter surges, according to national averages. This isn’t true for all regions, though: the Midwest in particular has reported very high SARS-CoV-2 levels in wastewater, comparable to or perhaps higher than last winter (depending on which dataset you look at). Viral levels have been high in the Northeast, too.

Healthcare system metrics similarly show declines or plateaus in national averages, with the highest levels in the Midwest, followed by the Northeast. Test positivity is starting to decline in Midwest health regions that reported the highest positivity rates this winter (Great Lakes, Central Plains). And the CDC’s disease forecasting center estimates that COVID-19 cases are “declining or likely declining” in 26 states as of January 20, including states across these regions.

Series of four charts from Biobot Analytics showing regional wastewater trends for influenza A, influenza B, RSV, and COVID-19 from the organization's testing network. In all four charts, the West is represented in green, South in pink, Midwest in purple, and Northeast in gold. The X axis represents time, spanning September 2024 to January 2026, and the Y axis represents effective concentration of virus, with different scales for each chart (the COVID-19 scale goes up to 1000 copies/mL, flu A goes up to 300 copies/mL, and flu B and RSV stay under 50 copies/mL). All charts show waves of these viruses in both winter 2024-25 and 2025-26; the COVID-19 chart also shows a summer 2025 wave. As of mid-January, levels of all four viruses are mostly declining, and all four show higher levels for the Midwest and Northeast compared to the West and South. Flu B levels may be going up in the West and Northeast.
Regional wastewater trends from Biobot Analytics, risk report for the week of January 17

In the coming weeks, I will be watching to see if the South and West report further increases in COVID-19 levels, as they have had a relatively milder winter of this disease so far. Notably, the CDC forecasting center estimates that cases are “growing or likely growing” in five states: Texas, Missouri, West Virginia, Virginia, and North Carolina. Test positivity is also increasing in the Mid-Atlantic states.

Meanwhile, while national flu metrics have continued to decline, there are potential signs that this winter’s flu wave could rebound. Epidemiologist Caitlin Rivers noted in her newsletter this week that flu activity went up in school-aged children: “Although the increase is small, kids are often the first to register new flu trends,” she wrote. The CDC forecasting center also estimates that flu cases are “growing or likely growing” in 27 states.

In other public health news: the U.S. is on the verge of losing its measles elimination status, as that disease has now spread in low-vaccination areas for a year. But one top CDC official “said he was unbothered by the prospect” at a media briefing last week, Amy Maxmen reported for KFF Health News. With measles, like with COVID-19, the Trump administration is downplaying ongoing spread and failing to promote prevention measures.

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