
More than 150,000 deaths from COVID-19 went uncounted in the U.S. in the first two years of the pandemic, according to a new study in Science Advances. Researchers used machine learning to evaluate death certificates from March 2020 to December 2021, and estimated that 19% more COVID-19 deaths occurred than originally reported.

Two recent prevalence studies showed the impact of Long COVID on Americans. The first, an electronic cohort study of over 600,000 active military personnel, found that 42% had at least one symptom more than 30 days after contracting COVID-19.

A large retrospective cohort study found significant healthcare cost increases for Long COVID over five years. The study was shared as a preprint in medRxiv and included the records of over 143,000 people.

Researchers identified high levels of cytokine interferon gamma (IFN-γ) in white blood cells as a potential biomarker for Long COVID. The small study, published in Science Advances, found that symptoms improved when production of IFN-γ (a molecule that plays an important role in immune response) decreased.

SARS-C0V-2 reinfections significantly increase the risk of Long COVID in children, a new National Institutes of Health (NIH) RECOVER study found.

A new review in Dovepress states that Long COVID, myalgic encephalomyelitis (ME), and postural orthostatic tachycardia syndrome (POTS) should be classified as neuroimmune disorders.

A large study recently connected “chronic absenteeism” to pediatric Long COVID, further disproving the “immunity debt” talking points from pundits earlier in the pandemic.

The Food and Drug Administration (FDA) has granted expanded access to the stem cell infusion RegeneCyte for Long COVID.

A large prospective cohort study published in Infectious Diseases found that a majority of people with Long COVID did not recover.

A new study in eBioMedicine found neurological Long COVID symptoms were associated with increased pTau-181 levels, a marker of brain inflammation that has been tied to Alzheimer’s disease.
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