National COVID-19 trends, July 1

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Bar chart titled, "Published Sequences from NS3, CDC Sequencing Contracts, and Other CDC Sequencing Efforts: Weekly Published Sequences." The X axis represents time, from January 2021 to May 2025, while the Y axis represents SARS-CoV-2 sequences published each week. The number of sequences published increased and decreased along with COVID-19 spread from 2021 through 2023 but generally stated over 10,000 per week, peaking near 100,000 in early 2022. Since mid-2023, the number of sequences published has declined dramatically, typically staying under 2,000 a week in 2025. The bars are color-coded, with dark blue representing sequences published by the CDC itself and light blue representing sequences published by public health laboratories (PHLs) and partners.
SARS-CoV-2 samples sequenced for variant information by the CDC and its partners, through May 2025.

Here are the latest national COVID-19 trends, according to the U.S. Centers for Disease Control and Prevention (CDC) and major wastewater surveillance providers:

  • About 0.7 in every 100,000 people were hospitalized for COVID-19 during the week ending June 14.
  • COVID-19 test positivity increased slightly, from 2.9% of COVID-19 tests returning positive results during the week ending June 14 to 3% during the week ending June 21.
  • SARS-CoV-2 concentration in wastewater has decreased 8% between the week ending June 14 and the week ending June 21, and the national wastewater viral activity level is “very low,” per the CDC.
  • SARS-CoV-2 concentration in wastewater decreased 3% between June 11 and June 18, and the national wastewater trend is “high,” per WastewaterSCAN.

This summer’s COVID-19 surge is still getting off to a rather slow start. While cases are clearly going up in parts of the West Coast and South, national averages mostly remain at moderate levels. It is possible that the new variant NB.1.8.1 has not actually arrived in significant numbers yet, though variant patterns are incredibly hard to follow as sequencing data are very limited in 2025 compared to earlier in the pandemic.

Wastewater data from the CDC, WastewaterSCAN, and Biobot Analytics all indicate that, at the national level, SARS-CoV-2 is still close to its between-surges baseline (or, as low as likely is possible without widespread public health measures). The CDC’s aggregated national average is the lowest it’s been since June 2023.

Regional data, however, show increasing disease spread in parts of the West Coast and South, continued from last week. WWSCAN reports more intense increases in the South as of mid-June, at testing sites in Florida, Georgia, Texas, Tennessee, Maryland, and other nearby states. The trend in California seems to have leveled off for now, but I’ll keep watching this state closely.

The CDC’s infectious disease forecasting center similarly reports that COVID-19 cases are “growing or likely growing” in eight states across the South and West, as of June 24: Maryland, Florida, Texas, Mississippi, Louisiana, Oklahoma, Oregon, and Washington. Test positivity data from the CDC indicate growing cases in these states, too.

Why haven’t we seen a more pronounced surge yet? One reason may be that the variant NB.1.8.1, nicknamed “Nimbus” and spreading widely on a global scale, has not actually reached the U.S. in significant numbers yet. While the CDC’s most recent variant estimates (from mid-June) indicated NB.1.8.1 was causing about one-third of recent U.S. cases, outside modelers such as J.P. Weiland and Mike Honey have suggested that the agency may have overestimated, and, in fact, another variant, called XFG, is more prevalent right now.

If those modelers are right, we could be seeing a slower increase in cases as neither newer variant has really taken off yet — or perhaps we’re even in for less transmission this summer than in 2023 or 2024. But I write this analysis with a great deal of uncertainty, as variant surveillance is quite limited in the U.S. these days. In earlier years of the pandemic, the CDC logged tens of thousands of sequenced SARS-CoV-2 samples each week, peaking at almost 100,000 during the first Omicron surge. Now, the agency counts just hundreds of sequences each week.

Also limited: any COVID-19 testing, period. According to recent survey results, reported in JAMA Network Open, about 30% of respondents (from about 2,000 U.S. adults) would not test themselves for COVID-19 if they suspected they had the disease. Half of those said they didn’t see a reason to test. The paper shows how much our so-called public health system has failed in educating people about basic safety tools.

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